The primary signal is desiredSize on the controller. It can be positive (wants data), zero (at capacity), negative (over capacity), or null (closed). Producers are supposed to check this value and stop enqueueing when it's not positive. But there's nothing enforcing this: controller.enqueue() always succeeds, even when desiredSize is deeply negative.
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Astronauts have handled many maladies over a quarter-century at the space station, but most, such as toothaches and earaches, aren't deadly. Astronauts also have managed minor injuries and infections, back pain, motion sickness, headaches, and vision changes with telemedicine and the onboard medical kit, according to public reports.