Both page table entries and segment descriptors have an Accessed bit that the hardware must set on use -- but the mechanisms are quite different.
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而在新的早期研发+CRO服务模式下，由于MNC提前介入且合作的项目数量更多（如石药-阿斯利康合作涵盖8个项目），首付款的支付更为前置和集中，里程碑付款的触发点也更为密集。更为关键的是，这种模式可能催生类CRO的常态化收入。信达生物与礼来的合作中，信达主导从药物发现至中国2期临床的研发工作，这意味着在长达数年的合作期内，信达生物将通过里程碑付款形式持续获得研发服务收入，而非传统的一次性授权收入。