In 2009, PacBio published a paper expanding the principle into a full-blown sequencing technique. Once again, each nucleotide was labeled with a different colored fluorophore detectable by the ZMW to determine which base had been incorporated. The fluorophores were attached such that they would be cleaved off during the chemical reaction incorporating the base into the growing DNA strand; they would then diffuse out of the ZMW so that the next fluorophore could be detected. Sequencing took place on a chip with many wells simultaneously — a different type of parallelization where each well detected a single DNA molecule undergoing the same basic chemical reaction.
自1992年入职以来，佐藤恒治参与过卡罗拉、普锐斯的部件开发。是雷克萨斯GS和LC车型的总工程师，也是雷克萨斯品牌的负责人。履历上看，佐藤恒治擅长造车搞研发，自然对研发投入十分关心。
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BBC Middle East correspondent Hugo Bachega reports from the Iranian-Armenian border as internet shutdown continues following deadly protests.
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